2022-03-07
Synthesis of Aspirin
Salicylic Acid + Acetic Anhydride + Sulfuric Acid: The solution became cloudy again during stirring due to aspirin crystallization.
Recrystallization: If hot water is used, the aspirin would remain dissolved and not recrystallize. Cold water, however, facilitates the formation of crystals as aspirin is less soluble in cold water.
Ethanoic Anhydride vs. Acetic Acid: Ethanoic anhydride is used instead of acetic acid because it promotes a faster and more complete reaction by stabilizing the reaction intermediates, allowing the esterification to proceed smoothly.
Sulfuric Acid (H+): The acid acts as a catalyst by forming reactive intermediates that drive the reaction forward.
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